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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
P02545
USC-OGP 2-DE database
:
P02545
P02545
General information about the entry
View entry in simple text format
Entry name
LMNA_HUMAN
Primary accession number
P02545
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Prelamin-A/C; Contains: RecName: Full=Lamin-A/C; AltName: Full=70 kDa lamin; AltName: Full=Renal carcinoma antigen NY-REN-32; Flags: Precursor;.
Gene name
Name=LMNA
Synonyms=LMN1
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1125
:
pI=6.92; Mw=75177
SPOT OGP-1132
:
pI=6.61; Mw=65162
SPOT OGP-1134
:
pI=6.89; Mw=63844
Cross-references
UniProtKB/Swiss-Prot
P02545; LMNA_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
LMNA_HUMAN
Primary accession number
P02545
Secondary accession number(s)
B4DI32 D3DVB0 D6RAQ3 E7EUI9 P02546 Q5I6Y4 Q5I6Y6 Q5TCJ2 Q5TCJ3 Q6UYC3 Q969I8 Q96JA2
Sequence was last modified on
March 20, 1987 (version 1)
Annotations were last modified on
March 15, 2017 (version 227)
Name and origin of the protein
Description
RecName: Full=Prelamin-A/C; Contains: RecName: Full=Lamin-A/C; AltName: Full=70 kDa lamin; AltName: Full=Renal carcinoma antigen NY-REN-32; Flags: Precursor;
Gene name
Name=LMNA
Synonyms=LMN1
Encoded on
Name=LMNA; Synonyms=LMN1
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Cardiomyopathy
;
Charcot-Marie-Tooth disease
;
Coiled coil
;
Complete proteome
;
Congenital muscular dystrophy
;
Direct protein sequencing
;
Disease mutation
;
Emery-Dreifuss muscular dystrophy
;
Intermediate filament
;
Isopeptide bond
;
Limb-girdle muscular dystrophy
;
Lipoprotein
;
Methylation
;
Neurodegeneration
;
Neuropathy
;
Nucleus
;
Phosphoprotein
;
Polymorphism
;
Prenylation
;
Reference proteome
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X03444; CAA27173.1
; ALT_FRAME; mRNA
EMBL
X03445; CAA27174.1
; -; mRNA
EMBL
M13451; AAA36164.1
; -; mRNA
EMBL
M13452; AAA36160.1
; -; mRNA
EMBL
AY847597; AAW32540.1
; -; mRNA
EMBL
AY847595; AAW32538.1
; -; mRNA
EMBL
AY357727; AAR29466.1
; -; mRNA
EMBL
AK295390; BAG58344.1
; -; mRNA
EMBL
AL135927; CAI15521.1
; -; Genomic_DNA
EMBL
AL135927; CAI15522.1
; -; Genomic_DNA
EMBL
AL355388; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AL356734; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471121; EAW52997.1
; -; Genomic_DNA
EMBL
CH471121; EAW52999.1
; -; Genomic_DNA
EMBL
BC000511; AAH00511.1
; -; mRNA
EMBL
BC003162; AAH03162.1
; -; mRNA
EMBL
BC014507; AAH14507.1
; -; mRNA
EMBL
AF381029; AAK59326.1
; -; mRNA
CCDS
CCDS1129.1; -. [P02545-1]
; .
CCDS
CCDS1131.1; -. [P02545-2]
; .
CCDS
CCDS58038.1; -. [P02545-4]
; .
CCDS
CCDS72941.1; -. [P02545-6]
; .
PIR
A02961; VEHULA
; .
PIR
A02962; VEHULC
; .
RefSeq
NP_001244303.1; NM_001257374.2. [P02545-4]
; .
RefSeq
NP_001269553.1; NM_001282624.1
; .
RefSeq
NP_001269554.1; NM_001282625.1. [P02545-2]
; .
RefSeq
NP_001269555.1; NM_001282626.1. [P02545-6]
; .
RefSeq
NP_005563.1; NM_005572.3. [P02545-2]
; .
RefSeq
NP_733821.1; NM_170707.3. [P02545-1]
; .
RefSeq
NP_733822.1; NM_170708.3. [P02545-3]
; .
UniGene
Hs.594444; -
; .
UniGene
Hs.706897; -
; .
UniGene
Hs.733671; -
; .
PDB
1IFR; X-ray
; 1.40 A; A=436-552
PDB
1IVT; NMR
; -; A=428-549
PDB
1X8Y; X-ray
; 2.20 A; A=305-387
PDB
2XV5; X-ray
; 2.40 A; A/B=328-398
PDB
2YPT; X-ray
; 3.80 A; F/G/H/I=661-664
PDB
3GEF; X-ray
; 1.50 A; A/B/C/D=436-552
PDB
3V4Q; X-ray
; 3.06 A; A=313-386
PDB
3V4W; X-ray
; 3.70 A; A=313-386
PDB
3V5B; X-ray
; 3.00 A; A=313-386
PDBsum
1IFR; -
; .
PDBsum
1IVT; -
; .
PDBsum
1X8Y; -
; .
PDBsum
2XV5; -
; .
PDBsum
2YPT; -
; .
PDBsum
3GEF; -
; .
PDBsum
3V4Q; -
; .
PDBsum
3V4W; -
; .
PDBsum
3V5B; -
; .
DisProt
DP00716; -
; .
ProteinModelPortal
P02545; -
; .
SMR
P02545; -
; .
BioGrid
110186; 225
; .
DIP
DIP-32948N; -
; .
DIP
DIP-58162N; -
; .
IntAct
P02545; 65
; .
MINT
MINT-5003995; -
; .
STRING
9606.ENSP00000357283; -
; .
ChEMBL
CHEMBL1293235; -
; .
iPTMnet
P02545; -
; .
PhosphoSitePlus
P02545; -
; .
SwissPalm
P02545; -
; .
BioMuta
LMNA; -
; .
DMDM
125962; -
; .
REPRODUCTION-2DPAGE
IPI00021405; -
; .
REPRODUCTION-2DPAGE
IPI00216952; -
; .
REPRODUCTION-2DPAGE
P02545; -
; .
SWISS-2DPAGE
P02545; -
; .
EPD
P02545; -
; .
MaxQB
P02545; -
; .
PaxDb
P02545; -
; .
PeptideAtlas
P02545; -
; .
PRIDE
P02545; -
; .
TopDownProteomics
P02545-1; -. [P02545-1]
; .
TopDownProteomics
P02545-2; -. [P02545-2]
; .
TopDownProteomics
P02545-4; -. [P02545-4]
; .
DNASU
4000; -
; .
Ensembl
ENST00000347559; ENSP00000292304
; ENSG00000160789. [P02545-3]; .
Ensembl
ENST00000368299; ENSP00000357282
; ENSG00000160789. [P02545-6]; .
Ensembl
ENST00000368300; ENSP00000357283
; ENSG00000160789. [P02545-1]; .
Ensembl
ENST00000368301; ENSP00000357284
; ENSG00000160789. [P02545-2]; .
Ensembl
ENST00000448611; ENSP00000395597
; ENSG00000160789. [P02545-4]; .
Ensembl
ENST00000473598; ENSP00000421821
; ENSG00000160789. [P02545-5]; .
GeneID
4000; -
; .
KEGG
hsa:4000; -
; .
UCSC
uc001fnf.3; human. [P02545-1]
; .
CTD
4000; -
; .
DisGeNET
4000; -
; .
GeneCards
LMNA; -
; .
GeneReviews
LMNA; -
; .
HGNC
HGNC:6636; LMNA
; .
HPA
CAB004022; -
; .
HPA
HPA006660; -
; .
MalaCards
LMNA; -
; .
MIM
115200; phenotype
; .
MIM
150330; gene
; .
MIM
151660; phenotype
; .
MIM
159001; phenotype
; .
MIM
176670; phenotype
; .
MIM
181350; phenotype
; .
MIM
212112; phenotype
; .
MIM
248370; phenotype
; .
MIM
275210; phenotype
; .
MIM
605588; phenotype
; .
MIM
610140; phenotype
; .
MIM
613205; phenotype
; .
MIM
616516; phenotype
; .
neXtProt
NX_P02545; -
; .
OpenTargets
ENSG00000160789; -
; .
Orphanet
79474; Atypical Werner syndrome
; .
Orphanet
280365; Autosomal codominant severe lipodystrophic laminopathy
; .
Orphanet
98853; Autosomal dominant Emery-Dreifuss muscular dystrophy
; .
Orphanet
264; Autosomal dominant limb-girdle muscular dystrophy type 1B
; .
Orphanet
98855; Autosomal recessive Emery-Dreifuss muscular dystrophy
; .
Orphanet
98856; Charcot-Marie-Tooth disease type 2B1
; .
Orphanet
157973; Congenital muscular dystrophy due to LMNA mutation
; .
Orphanet
2229; Dilated cardiomyopathy - hypergonadotropic hypogonadism
; .
Orphanet
300751; Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
; .
Orphanet
293899; Familial isolated arrhythmogenic ventricular dysplasia
; biventricular form; .
Orphanet
293888; Familial isolated arrhythmogenic ventricular dysplasia
; left dominant form; .
Orphanet
293910; Familial isolated arrhythmogenic ventricular dysplasia
; right dominant form; .
Orphanet
2348; Familial partial lipodystrophy
; Dunnigan type; .
Orphanet
79084; Familial partial lipodystrophy
; Kobberling type; .
Orphanet
168796; Heart-hand syndrome
; Slovenian type; .
Orphanet
740; Hutchinson-Gilford progeria syndrome
; .
Orphanet
137871; Laminopathy type Decaudain-Vigouroux
; .
Orphanet
54260; Left ventricular noncompaction
; .
Orphanet
1662; Lethal restrictive dermopathy
; .
Orphanet
363618; LMNA-related cardiocutaneous progeria syndrome
; .
Orphanet
90153; Mandibuloacral dysplasia with type A lipodystrophy
; .
Orphanet
99706; Progeria-associated arthropathy
; .
PharmGKB
PA231; -
; .
eggNOG
KOG0977; Eukaryota
; .
eggNOG
ENOG410Y2H6; LUCA
; .
GeneTree
ENSGT00830000128282; -
; .
HOGENOM
HOG000007711; -
; .
HOVERGEN
HBG013015; -
; .
InParanoid
P02545; -
; .
KO
K12641; -
; .
OMA
SHVSRHR; -
; .
OrthoDB
EOG091G063B; -
; .
PhylomeDB
P02545; -
; .
TreeFam
TF101181; -
; .
Reactome
R-HSA-1221632; Meiotic synapsis
; .
Reactome
R-HSA-2993913; Clearance of Nuclear Envelope Membranes from Chromatin
; .
Reactome
R-HSA-2995383; Initiation of Nuclear Envelope Reformation
; .
Reactome
R-HSA-352238; Breakdown of the nuclear lamina
; .
Reactome
R-HSA-381038; XBP1(S) activates chaperone genes
; .
Reactome
R-HSA-4419969; Depolymerisation of the Nuclear Lamina
; .
Reactome
R-HSA-6802952; Signaling by BRAF and RAF fusions
; .
Reactome
R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
; .
SIGNOR
P02545; -
; .
ChiTaRS
LMNA; human
; .
EvolutionaryTrace
P02545; -
; .
GeneWiki
LMNA; -
; .
GenomeRNAi
4000; -
; .
PMAP-CutDB
P02545; -
; .
PRO
PR:P02545; -
; .
Proteomes
UP000005640; Chromosome 1
; .
Bgee
ENSG00000160789; -
; .
CleanEx
HS_LMNA; -
; .
ExpressionAtlas
P02545; baseline and differential
; .
Genevisible
P02545; HS
; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0031012; C:extracellular matrix
; IDA:BHF-UCL; .
GO
GO:0005882; C:intermediate filament
; TAS:UniProtKB; .
GO
GO:0005638; C:lamin filament
; TAS:UniProtKB; .
GO
GO:0005635; C:nuclear envelope
; IDA:UniProtKB; .
GO
GO:0005652; C:nuclear lamina
; TAS:UniProtKB; .
GO
GO:0031965; C:nuclear membrane
; IDA:UniProtKB; .
GO
GO:0016607; C:nuclear speck
; IEA:UniProtKB-SubCell; .
GO
GO:0005654; C:nucleoplasm
; TAS:Reactome; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0048471; C:perinuclear region of cytoplasm
; IDA:UniProtKB; .
GO
GO:0042802; F:identical protein binding
; IPI:IntAct; .
GO
GO:0005198; F:structural molecule activity
; TAS:UniProtKB; .
GO
GO:0071456; P:cellular response to hypoxia
; IEP:UniProtKB; .
GO
GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity
; ISS:BHF-UCL; .
GO
GO:0036498; P:IRE1-mediated unfolded protein response
; TAS:Reactome; .
GO
GO:0007077; P:mitotic nuclear envelope disassembly
; TAS:Reactome; .
GO
GO:0007084; P:mitotic nuclear envelope reassembly
; TAS:Reactome; .
GO
GO:0007517; P:muscle organ development
; IMP:UniProtKB; .
GO
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
; IEA:Ensembl; .
GO
GO:0072201; P:negative regulation of mesenchymal cell proliferation
; IEA:Ensembl; .
GO
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria
; IEA:Ensembl; .
GO
GO:0090343; P:positive regulation of cell aging
; IDA:UniProtKB; .
GO
GO:0034504; P:protein localization to nucleus
; ISS:UniProtKB; .
GO
GO:0030334; P:regulation of cell migration
; ISS:BHF-UCL; .
GO
GO:1900180; P:regulation of protein localization to nucleus
; IEA:Ensembl; .
GO
GO:0035105; P:sterol regulatory element binding protein import into nucleus
; IEA:Ensembl; .
GO
GO:0055015; P:ventricular cardiac muscle cell development
; IEA:Ensembl; .
Gene3D
2.60.40.1260; -
; 1; .
InterPro
IPR001664; IF
; .
InterPro
IPR018039; Intermediate_filament_CS
; .
InterPro
IPR001322; Lamin_tail_dom
; .
PANTHER
PTHR23239; PTHR23239
; 1; .
Pfam
PF00038; Filament
; 1; .
Pfam
PF00932; LTD
; 1; .
SMART
SM01391; Filament
; 1; .
SUPFAM
SSF74853; SSF74853
; 1; .
PROSITE
PS00226; IF
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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